Hypertrophic Cardiomyopathy: Cov tsos mob, Ua rau, Kho thiab Tiv Thaiv Saib Cov Qauv Rau Cov Lus Ceeb Toom Ceev Tag Nrho Cov Ntawv Ceeb Toom Rau Cov Lus Qhia Txhua HnubTsuas Nyob Hauv
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Kev pheej hmoo txaus ntshai rau COVID-19 suav nrog hnub nyoog, poj niam txiv neej, kub siab, ntshav qab zib thiab rog. Tsis ntev los no, qee cov pov thawj hauv cov kab mob thiab cov kev tshawb fawb tau qhia tias muaj kev sib raug zoo ntawm PCOS thiab COVID-19.
Cov kev tshawb fawb hais tias cov poj niam uas muaj mob los ntawm polycystic ovary syndrome (PCOS) lossis tus mob polycystic ovarian (PCOD) tuaj yeem muaj kev pheej hmoo ntau ntawm cov kab mob QHID-19 piv rau cov poj niam tsis muaj PCOS. Kab lus no yuav tham txog tias yog vim li cas thiab vim li cas nws thiaj li ua tau. Nyeem rau kom paub ntau ntxiv.
COVID-19 Thiab Cov Poj Niam Raug Txom Nyem Los Ntawm PCOS
Raws li kev tshawb fawb tshaj tawm hauv European Journal Of Endocrinology, cov poj niam nrog PCOS nyob rau ntawm 28 feem pua muaj kev pheej hmoo kis tus mob los ntawm COVID-19 piv rau cov poj niam tsis muaj tus mob. Qhov txiaj ntsig tau muab xam tom qab kho lub hnub nyoog, BMI thiab kev pheej hmoo txaus ntshai. [1]
Tsis tas li tau hais tseg kev hloov kho, qhov kev soj ntsuam tau pom tias PCOS cov poj niam nyob ntawm 51 feem pua ntau dua ntawm Kev PAB-19 ntawm cov poj niam tsis muaj PCOS.
Vim li cas PCOS Cov Neeg Mob Tau Raug Mob Ntau
Raws li niaj hnub no, COVID-19 tau cuam tshuam rau 124 lab tus tib neeg thoob ntiaj teb, nrog 70,1 lab tau rov kis tus mob thiab 2.72 lab tuag tas. Ntau cov kev tshawb fawb luam tawm tau pom tias qhov kev kuaj pom tseeb COVID-19 cov neeg muaj ntau hauv cov txivneej hauv ntau lub tebchaws piv rau poj niam.
Txawm hais tias qhov ua rau yog multifactorial, qhov cuam tshuam ntawm androgen hormone yog suav tias yog ib qho ntawm cov laj thawj tseem ceeb rau kev sib deev tshwj xeeb sib txawv hauv tus nqi sib kis.
Androgen feem ntau hais txog txiv neej cov tshuaj hormones uas tswj kev txhim kho thiab kev saib xyuas ntawm tus txiv neej cov xeeb ceem thiab lawv cov kev ua me nyuam. [ob]
Qhov tshuaj yeeb no, txawm li cas los xij, tam sim no nyob rau hauv txiv neej thiab poj niam, tab sis nws lub luag haujlwm tseem ceeb yog kom txhawb kev sim testosterone thiab androstenedione, ob ntawm ob peb hom txiv neej poj niam txiv neej.
PCOS yog qhov mob endocrine nyob rau theem uas androgens (txiv neej hormone) nce siab, tsis txhob siv cov tshuaj estrogen (poj niam poj niam). Qhov no ua rau hyperandrogenism thiab zes qe menyuam muaj teeb meem, ua rau muaj kev ua qias neeg nyob hauv qee yam tsis muaj kev kuaj mob thiab kho mob kom zoo.
Raws li androgen cov tshuaj hormones yog suav tias yog qhov tseem ceeb ua rau muaj kev pheej hmoo ntawm COVID-19, nws tuaj yeem hais tias PCOS cov poj niam tuaj yeem kis tus mob ntau dua, xav tias lwm yam tseem ceeb xws li kev rog rog hauv PCOS cov poj niam tuaj yeem yog qhov tseem ceeb.
Lwm Yam Koom Tes
1. Cov tshuaj insulin tsis kam
PCOS tau sib txuas rau cov teeb meem metabolic xws li insulin tsis kam thiab ntshav qab zib. Cov tshuaj Insulin yog ib yam tshuaj uas pab tswj cov piam thaj hauv lub cev, nrog rau kev tswj cov metabolism hauv cov protein thiab lipids.
Insulin tsis kam yog tsim thaum lub cev tsis teb rau insulin, ua rau tsis siv ntshav qabzib hauv cov ntshav rau lub zog, ua rau cov ntshav qabzib ntau ntxiv. Qhov ntau dhau ntawm cov piam thaj pib cuam tshuam nrog cov kab mob tiv thaiv kab mob xws li B hlwb, macrophages thiab T cell, uas ua rau txo qis hauv kev ua haujlwm hauv lub cev.
Kev tsis ua haujlwm ntawm lub cev tiv thaiv vim insulin tsis kam, uas tau pib vim PCOS thaum kawg tuaj yeem hais tias vim li cas cov poj niam nrog PCOS tau txais kev cuam tshuam heev ntawm cov kab mob coronavirus. [3]
2. rog dhau
Ib txoj kev tshawb nrhiav tau qhia tias tsis ntev tom qab muaj tus kabmob coronavirus, ntawm cov neeg ua pa, ntawm cov neeg mob rog yog cov neeg coob, tom qab tau nce ntawm kev tuag ntawm cov neeg no. [4]
Lwm qhov kev tshawb fawb tseem qhia ntxiv txog qhov tseeb tias lub sijhawm yav dhau los kev kis tus kabmob H1N1 lossis swine flu, qhov xwm txheej loj ntawm cov neeg mob rog coob. [5]
tshem tawm hnub ci nyob hauv tsev
Nyob ib ncig ntawm 38-88 rau ib xees ntawm cov poj niam nrog PCOS pom tias rog dhau los yog rog dhau. Cov kev sib txuas ze ntawm cov rog, PCOS thiab COVID-19 tuaj yeem xaus, tias PCOS cov poj niam muaj kev cuam tshuam ntau rau COVID-19 vim yog rog dhau heev lossis rog dhau.
3. Kev tsis txaus Vitamin D
Muaj ntau cov Vitamin D tsis zoo txuas rau PCOS thiab COVID-19 kev kis kab mob nyob rau ntau txoj hauv kev. Vitamin D yog cov vitamins tseem ceeb uas tuaj yeem pab tiv thaiv kev ua pa ntawm COVID-19 los ntawm nws lub zog tiv thaiv kab mob thiab txo qis cytokines ua rau mob ntsws.
Nyob ib ncig ntawm 67-85 ib xees ntawm cov poj niam nrog PCOS, muaj kev pom zoo siab kawg ntawm cov vitamin D. [6]
Qhov tsis muaj vitamin D tuaj yeem ua rau lub cev tsis muaj zog, mob cytokines ntau ntxiv thiab muaj kev pheej hmoo ntawm comorbidities zoo li ntshav qab zib, insulin tsis kam thiab rog rog, txhua yam teeb meem rau PCOS.
Yog li, nws tuaj yeem hais tias muaj cov vitamin D tsis txaus tuaj yeem txuas nrog PCOS thiab muaj kev nyuaj siab thiab cov neeg tuag ntau vim yog KEVID-19.
4. Cov microbiota zoo
Plab dysbiosis lossis ua rau lub plab microbiota cuam tshuam nrog kev mob nkeeg xws li PCOS.
PCOS thiab lub plab mob mus tes ua ke. Cov poj niam nrog PCOS yog ib txwm pom muaj plab dysbiosis. Txawm li cas los xij, yog tias cov piam thaj hauv qab tau tswj tau zoo thiab lub plab ua haujlwm tau txais kev saib xyuas hauv PCOS, kev noj qab haus huv lub plab tuaj yeem hloov kho.
Kev hloov pauv nyob rau hauv kev sib xyaw ua ke ntawm lub plab microbiome tuaj yeem cuam tshuam rau kev tiv thaiv kab mob, thawj qhov system ntawm lub cev uas tiv thaiv peb los ntawm kev kis kab mob thiab yog li, ua rau peb muaj kev kis mob xws li COVID-19.
Kev siv cov probiotics kom muaj qhov sib npaug ntawm cov plab hnyuv microbiota tuaj yeem pab txhawb kev tiv thaiv kab mob thiab tiv thaiv kev pheej hmoo ntawm COVID-19.
Mus Xaus
Cov tshuaj Insulin tuaj yeem nce ntau ntxiv ntawm androgens hauv cov poj niam nrog PCOS. Kev rog dhau thiab rog dhau tuaj yeem ua rau cov insulin tsis kam thiab ua li no, txhim kho androgen ntau lawm. Qhov no yuav ua rau lub cev tsis muaj zog tiv thaiv kab mob vim yog lub cev endocrine-lub cev tsis muaj zog, uas tom qab ntawd tuaj yeem nce qhov kev pheej hmoo ntawm COVID-19 hauv PCOS cov poj niam.
